AstraZeneca
Clinical Pharmacometrician
$125K–$187K
US - South San Francisco - CA · Full-time · Posted Oct 18, 2026
- Experience
- 0–3 years of industry drug development experience in pharmacometrics supporting decision-making, dose selection, study design, and regulatory interactions.
- Education
- PhD in pharmacometrics, pharmacokinetics, biostatistics, or related field.
About the job
Develops quantitative modeling strategies for AstraZeneca’s cell therapy portfolio to optimize dosing, guide clinical development decisions, and support regulatory submissions.
What you'll do
- Build population PK, PKPD, exposure–response, mechanistic, and empirical models to support clinical studies and development decisions.
- Advise on trial design, dose selection, regulatory submissions, and model-informed drug development strategies.
- Monitor emerging methodologies and advance cell therapy modeling through speaking, publications, and consortium participation.
What they ask for
- PhD in pharmacometrics, pharmacokinetics, biostatistics, or a related field.
- Hands-on experience and advanced proficiency with pharmacometrics software.
- Knowledge of global regulatory, compliance, processes, standards, and issues specific to pharmacometrics.
- Ability to plan and implement pharmacometrics approaches that inform dose selection and go/no-go decisions.
Nice to have
- Experience applying AI and ML in pharmacometrics.
- Pharmacometrics experience across cell therapy platforms and disease areas.
Pay
$124,713.60 - $187,070.40 USD base salary
Tools
NONMEM, Phoenix/NLME, R, SAS, Python, MATLAB
AI focus
Integrate AI-enabled analyses and biomarkers into quantitative pharmacology; monitor and adopt AI/ML methods for biomarker integration. AI/ML pharmacometrics experience is preferred.
Model-written summary · the original posting is authoritative