AstraZeneca
Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences (Cambridge, MA or Gaithersburg, MD)
$185K–$277K
US - Gaithersburg - MD · Director · Full-time · Posted Oct 20, 2026
- Experience
- Typically at least 10 years in project, investigative, regulatory toxicology, or related safety-focused roles in pharmaceutical, biotechnology, or CRO sectors; alternatively, a minimum bachelor’s degree and substantial additional pharmaceutical industry experience, including approximately 15 or more years of relevant experience.
- Education
- PhD, DABT, or an advanced university degree in toxicology, pharmacology, oncology, or a related scientific discipline; alternatively, minimum bachelor’s degree via the stated experience pathway.
About the job
Leads toxicology and safety strategies for targeted oncology therapies, supporting candidate selection, development decisions, and regulatory submissions.
What you'll do
- Design and oversee regulatory and investigative toxicology programs to identify and mitigate safety risks.
- Provide data-driven toxicology recommendations across discovery and development, integrating in vitro, in silico, and in vivo approaches.
- Present safety assessments to governance bodies and contribute to regulatory submissions, external evaluations, and collaborations.
What they ask for
- PhD, DABT, or an advanced university degree in toxicology, pharmacology, oncology, or a related scientific discipline, with a strong scientific track record.
- Deep understanding of oncology drug discovery and development, including toxicology programs supporting IND filings and development milestones.
- Experience using in vitro, in silico, and in vivo tools to predict and characterize clinical safety risks.
- Ability to coordinate projects across functions and geographies, with strong scientific communication and influencing skills.
Nice to have
- Experience with radioconjugates or ADCs.
- Familiarity with small-molecule oncology therapeutics.
Pay
$184,538 and $276,808 USD Annual (base salary)
Tools
radioconjugates, antibody–drug conjugates (ADCs), small molecules, organ-on-chip, imaging, omics, in vitro, in silico, in vivo
Model-written summary · the original posting is authoritative