AstraZeneca
Senior Scientist, Allogeneic T-Cell Therapy Process Development
$112K–$168K
US - Gaithersburg - MD · Senior · Full-time · Posted Oct 27, 2026
- Experience
- BS with >6 years of relevant experience, or MS with a minimum of 4 years, or PhD with a minimum of 1 year of relevant proven experience.
- Education
- BS in Biochemical Engineering, Biomedical Engineering, Biotechnology, or related field; or MS; or PhD.
About the job
Develops, optimizes, characterizes, and scales manufacturing processes for allogeneic CAR-T and TCR-T cell therapies, supporting clinical manufacturing and technology transfer.
What you'll do
- Design, execute, analyze, interpret, and document process development studies, including hands-on T-cell culture, gene editing, expansion, scale-up, and characterization.
- Support technology transfer and clinical manufacturing readiness through documentation, troubleshooting, deviation investigations, change control, process monitoring, and risk assessments.
- Collaborate across functions and mentor junior scientists; contribute to development reports, publications, patents, and regulatory filings.
What they ask for
- Human primary-cell culture, including T-cell culture, and strong flow cytometry/T-cell characterization experience.
- Cell engineering in scale-up processes using manufacturing-ready genome-editing tools and DNA/RNA transfection approaches.
- Knowledge of upstream and downstream cell-therapy process development, including laboratory work and technology transfer.
- Fundamentals of DOE, strong experimental design and data analysis, troubleshooting, teamwork, communication, and technical writing skills.
Nice to have
- Immunology; CRISPR/Cas9, base editing, or viral transduction experience; GMP experience.
- Cell characterization experience with dPCR, ELISA, or NGS.
Pay
$112,304.00 - $168,456.00 USD (base salary)
Tools
CAR-T, TCR-T, flow cytometry, DOE, CRISPR/Cas9, base editing, DNA/RNA transfection, dPCR
Model-written summary · the original posting is authoritative