Flagship Pioneering
Associate Director, LNP Manufacturing
$154K–$204K
Cambridge, MA USA +1 · Director · Full-time · Posted Oct 22, 2026
- Location
- Cambridge, MA USA
Serif Biomedicines - Experience
- Relevant industry experience required; no number of years stated.
- Education
- Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering.
About the job
Leads lipid nanoparticle (LNP) manufacturing and process development, scaling formulations for development and in vivo studies while managing a team of scientists and engineers.
What you'll do
- Lead LNP scale-up from small R&D formulations to nonhuman primate (NHP) scale, including upstream and downstream process development.
- Develop targeted LNPs and micro- to mid-scale formulations, and integrate analytical methods into process development.
- Lead and mentor scientists and engineers and collaborate across departments to support in vivo studies.
What they ask for
- Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering, plus relevant industry experience.
- Hands-on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics.
- Working knowledge of mixing platforms and TFF, and familiarity with LNP analytical methods.
- Understanding of lipid and LNP design, stability, critical product attributes, molecular biology, and nucleic acid therapeutics; experience managing and mentoring junior scientists.
Nice to have
- Experience scaling in a GMP environment, managing CDMOs, or taking LNPs to the clinic, including agency interactions.
- Experience with tLNP conjugation at scale, lipid synthesis, purification, and compositional analysis.
Pay
$154,000 - $203,500 USD base salary
Tools
T-mix, impingement, TFF, microfluidics, NanoAssemblr, DLS, HPLC/CAD, LC-MS
AI focus
Applicants’ data may be reviewed using AI-assisted screening tools.
Model-written summary · the original posting is authoritative