Flagship Pioneering
Director, Pharmacology
$180K–$248K
Somerville, MA USA +1 · Director · Full-time · Posted Aug 26, 2026
- Location
- Somerville, MA USA
Cambridge, Massachusetts, United States - Experience
- 10-15+ years of relevant experience in biotech or pharmaceutical drug discovery and development.
- Education
- PhD in biology, pharmacology, or a related scientific discipline.
About the job
Lead preclinical pharmacology and translational strategy across discovery programs, integrating biology, PK/PD, DMPK, and in vivo data to guide candidate advancement.
What you'll do
- Set pharmacology strategy and interpret PK/PD, exposure-response, target coverage, and biomarker data across programs.
- Integrate cross-functional data, define critical experiments, and advise program decisions from early discovery through candidate selection.
- Oversee outsourced pharmacology studies and CRO relationships; communicate findings and recommendations to scientific teams.
What they ask for
- PhD in biology, pharmacology, or a related scientific discipline.
- Strong preclinical pharmacology experience translating biology into in vivo efficacy and PK/PD insight.
- Experience connecting in vitro findings to in vivo outcomes, including target engagement, exposure-response, and translational biomarkers.
- Experience partnering across biology, chemistry, pharmacology, DMPK, and external collaborators, including managing and interpreting CRO studies.
Nice to have
- Experience in hematology, particularly with oncology, or in inflammation or immunology programs.
- Strong publication record or experience in smaller, cross-functional biotech environments.
Pay
$180,000 - $248,000 (base salary)
Tools
AI, single-cell omics
AI focus
The company uses AI and single-cell omics for drug discovery; the role description does not specify direct AI responsibilities.
Model-written summary · the original posting is authoritative