Flagship Pioneering
Director/Senior Director, Computational Chemistry
$176K–$294K
Cambridge, MA USA +1 · Director · Full-time · Posted Oct 22, 2026
- Location
- Cambridge, MA USA
FL111 - Experience
- 10+ years of relevant industry experience, including scientific leadership and people management experience.
- Education
- PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or a related discipline.
About the job
Leads computational chemistry strategy and molecular design to optimize heterobifunctional small molecules across drug discovery programs.
What you'll do
- Direct molecular design, linker and ligand selection, and compound prioritization across programs.
- Lead cheminformatics strategy, computational workflows, and assessment of ADME and developability properties.
- Advance structure-based and AI/ML-assisted modeling, collaborate across scientific teams, and build and mentor the computational chemistry function.
What they ask for
- PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or a related discipline.
- Deep expertise in computational medicinal chemistry and structure-based drug design in binary and ternary settings.
- Track record of making impactful decisions across multiple drug discovery programs and creating synthetically actionable molecular designs.
- Experience using cheminformatics tools for compound design, analysis, and prioritization; demonstrated scientific leadership and people management.
Nice to have
- Experience with heterobifunctional small molecules (e.g., PROTACs) and ADME optimization for large, flexible molecules.
- Experience in an early-stage or startup biotech environment.
Pay
$176,000 - $294,300 USD base salary
Tools
cheminformatics, docking, conformational analysis, FEP, AI/ML
AI focus
Champion and advance AI/ML-assisted modeling capabilities to guide ligand selection, attachment strategy, and linker design. Applicant data may also be reviewed using AI-assisted screening tools.
Model-written summary · the original posting is authoritative