Flagship Pioneering
Principal Scientist, Machine Learning
$208K–$286K
Cambridge, MA USA +1 · Principal · Full-time · Posted Aug 5, 2026
- Location
- Cambridge, MA USA
Pioneering Intelligence - Experience
- 5+ years' scientific, engineering, or computational experience in academic, pharmaceutical, or biotechnology settings.
- Education
- Master’s, or PhD in a relevant field (e.g., machine learning, mathematics, statistics, computational sciences).
About the job
Leads AI/ML and computational biology projects and develops agentic systems to accelerate pharmaceutical R&D across preclinical, translational, and clinical programs.
What you'll do
- Lead and report on AI/ML and computational projects across ventures and Pioneering Medicines programs.
- Build, scale, benchmark, and maintain agentic systems integrating machine-learning and computational biology tools into research workflows.
- Coordinate and mentor cross-functional teams, contribute to project planning, and communicate technical findings and strategies.
What they ask for
- Master’s or PhD in a relevant field, such as machine learning, mathematics, statistics, or computational sciences.
- 5+ years' scientific, engineering, or computational experience in academic, pharmaceutical, or biotechnology settings.
- Experience driving results through teams and a record of leadership and contribution to AI/ML model decisions.
- Depth across Python, modern ML frameworks (PyTorch or JAX/TensorFlow), version control, databases, deep learning architectures, and relevant informatics software.
Nice to have
- Industry AI/ML experience.
- Experience with agentic AI and orchestration frameworks, LLM platforms, and agent evaluation or feedback-loop frameworks.
Pay
$208,000 - $286,000 USD base salary
Tools
Python, PyTorch, JAX, TensorFlow, Pydantic AI, LangGraph, LangChain, CrewAI
AI focus
Develops and deploys AI/ML, computational biology methods, LLM-based agents, and agentic workflows for pharmaceutical R&D and scientific research automation.
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