Flagship Pioneering
Principal / Senior Principal Scientist, DMPK
$179K–$236K
Cambridge, MA USA +1 · Principal · Full-time · Posted Jul 8, 2026
- Location
- Cambridge, MA USA
Cambridge, Massachusetts, United States - Experience
- 8+ years of industry experience in DMPK or a closely related function.
- Education
- PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field.
About the job
Leads DMPK strategy and bioanalytical work for nonclinical and clinical programs, guiding studies, data interpretation, dose selection, and regulatory support for tRNA therapeutics.
What you'll do
- Oversee bioanalytical assays and PK/PK-PD studies, including work with CROs and external laboratories.
- Analyze and present PK, PK-PD, and translational biomarker data to support dose selection and development decisions.
- Author nonclinical regulatory documents and lead DMPK contributions to cross-functional programs.
What they ask for
- PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or a related field.
- 8+ years of industry experience in DMPK or a closely related function.
- Working knowledge of bioanalytical methods and experience overseeing their development, qualification, validation, and sample analysis.
- Experience designing and overseeing in vivo nonclinical PK and PK-PD studies; hands-on PK/PK-PD data analysis; translational or clinical biomarker development; regulatory scientific writing; and supervising scientists.
Nice to have
- Experience in rare disease or genetic medicine and RNA-based therapies.
- Familiarity with LNP platform biology, GLP toxicology study design, ICH nonclinical guidelines, or MSD/Luminex multiplex immunoassays.
Pay
$179,000 - $236,000 USD base salary
Tools
LC-MS/MS, ligand binding assays, NGS, Phoenix WinNonlin, LNP, MSD, Luminex
AI focus
The posting states that application data may be reviewed using AI-assisted screening tools; this is not a job duty.
Model-written summary · the original posting is authoritative