Flagship Pioneering
Research Associate, Protein Production
$65K–$94K
Cambridge, MA USA +1 · Full-time · Posted Oct 6, 2026
- Location
- Cambridge, MA USA
FL116 - Experience
- Bachelor’s: 1–4 years of relevant academic and/or industry experience; master’s: 0–2 years of commercial experience.
- Education
- Bachelor’s degree in biochemistry, molecular biology, biotechnology, bioengineering, synthetic biology, or a related scientific discipline; or a master’s degree.
About the job
Produces and characterizes recombinant proteins at preparative and high-throughput scales to support the company’s design–build–test workflows.
What you'll do
- Run multi-liter bacterial protein expression and preparative purification, troubleshooting methods and improving yield and purity.
- Execute parallel, plate-based protein production, automated purification, sample normalization, and high-throughput analytics.
- Maintain instruments and meticulous sample records, and adapt workflows between preparative and high-throughput scales.
What they ask for
- Hands-on recombinant protein expression in E. coli, including multi-liter culture growth and harvest.
- Direct experience designing, operating, and troubleshooting ÄKTA FPLC methods in UNICORN, with proficiency in multiple column purification modalities.
- Experience with both preparative purification to milligram-or-greater quantities and plate-based production and analytics across large sample sets.
- Bachelor’s degree in a related scientific discipline with 1–4 years of relevant experience, or master’s degree with 0–2 years of commercial experience.
Nice to have
- Experience with magnetic-bead purification platforms such as Thermo KingFisher; familiarity with cell-free or yeast expression.
- Experience programming liquid handlers or robotic workstations; familiarity with Excel, Python, ELN, or LIMS.
Pay
$65,000 - $93,500 USD base salary
Tools
E. coli, ÄKTA FPLC, UNICORN, KingFisher, Hamilton, Tecan, Opentrons, Bravo
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