Flagship Pioneering
Scientist I, In Vitro Pharmacology
$100K–$126K
Watertown, MA USA +1 · Full-time · Posted Oct 7, 2026
- Location
- Watertown, MA USA
Abiologics, Inc - Experience
- Up to 2 years of relevant experience; industry experience preferred.
- Education
- PhD in molecular or cell biology or related discipline.
About the job
Develops and runs biochemical and cell-based pharmacology assays to assess Syntein activity, target engagement, and mechanism of action in support of drug discovery programs.
What you'll do
- Design, develop, and optimize cell-based and biochemical assays and screening workflows.
- Collaborate across pharmacology, computational design, and chemistry teams to advance design-make-test cycles and report findings.
- Contribute to in vivo and ex vivo pharmacology activities as needed.
What they ask for
- PhD in molecular biology, cell biology, or a related discipline.
- Expertise in mammalian cell culture, including cell-line maintenance, transfection, lentiviral transduction, and reporter cell lines.
- Proficiency in cell-based assays and bioanalytical techniques, including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays.
- Experience with primary cell culture and characterization, assay development, and independently designing and interpreting cell-based functional assays.
Nice to have
- Industry experience; cellular/high-content imaging and image analysis (e.g., Incucyte, Phenix).
- Renal disease biology, preclinical kidney models, in vivo pharmacology, and laboratory automation or semi-automated screening workflows.
Pay
$100,000 - $126,500 USD base salary
Tools
TR-FRET, Lumit, ELISA, Western blot, flow cytometry, Incucyte, Phenix, lentiviral transduction
AI focus
Application data may be reviewed using AI-assisted screening tools; no AI development work is stated.
Model-written summary · the original posting is authoritative