Flagship Pioneering
(Senior) Scientist - Translational Modeling & Decision Science
$115K–$205K
Cambridge, MA USA +1 · Senior · Full-time · Posted Jul 9, 2026
- Location
- Cambridge, MA USA
Pioneering Intelligence - Experience
- 3 to 7 years of industry experience.
- Education
- PhD in a life sciences discipline with quantitative experience, or in a quantitative life sciences discipline (pharmacometrics, systems pharmacology, computational biology, biomedical engineering, or equivalent).
About the job
Build mechanistic models and quantitative analyses to support translational drug-development and investment decisions across Flagship’s portfolio, while improving AI-platform outputs.
What you'll do
- Deliver evidence-based translational predictions and recommendations for diligence, milestones, program decisions, and competitive assessments.
- Identify relevant patterns and risks across programs and match analytical rigor to each decision’s context and consequences.
- Evaluate AI-generated outputs, prototype modeling approaches, and turn findings into product requirements, benchmarks, and feedback for engineering teams.
What they ask for
- PhD in a life sciences discipline with quantitative experience, or in a quantitative life sciences discipline (or equivalent), with strong knowledge of physiology, molecular biology, and immunology.
- Demonstrated expertise building mechanistic models for drug-development decisions across multiple therapeutic areas.
- Proficiency in Python scientific computing (scipy, numpy, pandas) and numerical ODE integration.
- Experience operating across multiple concurrent programs and decision types; ability to communicate recommendations to non-technical decision-makers.
Nice to have
- Experience applying frontier AI and LLM tools to drug-development decisions.
- Translational breadth across drug modalities, familiarity with regulatory credibility frameworks, or experience in venture-backed or platform-company environments.
Pay
$115,000 - $205,000 USD base salary
Tools
Python, scipy, numpy, pandas, ICH M15, FDA MIDD
AI focus
Apply AI and LLM tools to drug-development decisions; evaluate autonomous outputs and provide domain-expert feedback, benchmarks, and product requirements to improve an agentic AI platform.
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