Tilde Bio: Bioconjugation Chemistry Co-Op

What you'll do

• Design and run experiments to discover and optimize protein and peptide bioconjugation reactions; synthesize, purify, and characterize small-molecule reagents, linkers, and probes.
• Screen reaction conditions and assess kinetics, selectivity, yield, conjugate stability, and effects on protein structure and function.
• Characterize protein conjugates using intact-protein LC-MS and related methods; analyze and present results and maintain detailed electronic lab notebook records.

What they ask for

• Currently pursuing an M.S. in Chemistry, Chemical Biology, Biochemistry, or a closely related field.
• Strong foundation in organic synthesis, including multistep synthesis, purification, and characterization.
• Hands-on experience with analytical techniques such as NMR and LC-MS, and ability to extract structural information from spectra.
• Working knowledge of protein chemistry, including handling, purification, and buffer considerations.

Nice to have

• Previous research or industry experience in bioconjugation, chemical biology, or protein modification.
• Familiarity with antibody or protein conjugate modalities.

Pay

$25–$35 per hour (hourly pay)

Tools

NMR, LC-MS, intact-protein LC-MS, electronic lab notebook

AI focus

Applicant data may be reviewed using AI-assisted screening tools; the role itself does not describe AI work.