Principal Scientist, Target Binding

What you'll do

• Lead target-binding strategy and develop quantitative protein–protein interaction and cell-binding assays, including for challenging molecular systems.
• Advance measurement technologies and establish standards for assay quality, data processing, reproducibility, and interpretation.
• Partner across programs, communicate findings, and manage, mentor, and develop junior scientists and research associates.

What they ask for

• Ph.D. in biochemistry, biophysics, analytical chemistry, protein science, chemical biology, or a related discipline.
• At least 8+ years of relevant industry experience.
• Extensive industry experience developing and applying quantitative protein–protein interaction and target-binding assays; expertise with multiple technologies, including SPR, BLI, KinExA, and cell-binding assays.
• Experience leading scientific strategy across cross-functional programs and managing, mentoring, and developing scientists or research associates.

Nice to have

• Experience with biotherapeutic analytics and developability assessment, laboratory automation, high-throughput experimentation, or computational data pipelines.
• Proficiency with scripting, quantitative modeling, data science, or machine-learning workflows; practical experience with AI-enabled or agentic tools.

Pay

$160,000 — $224,000 USD per year base salary

Tools

SPR, BLI, KinExA, machine-learning

AI focus

Applies quantitative, statistical, machine-learning, and agentic approaches to improve experimental design, data analysis, troubleshooting, and scientific decision-making; preferred experience includes AI-enabled or agentic tools.