Generate Biomedicines
Scientist I, Synthetic Biology
$102K–$130K
Somerville, MA +1 · Full-time · Posted Oct 15, 2026
- Location
- Somerville, MA
Somerville, Massachusetts, United States - Experience
- PhD with 0–1 year of experience; alternatively, bachelor’s or master’s degree with at least 6 years of highly relevant experience.
- Education
- PhD in synthetic or systems biology, bioengineering, or a related field; alternatively, a bachelor’s or master’s degree with at least 6 years of highly relevant experience.
About the job
Develop pooled synthetic biology screens to identify protein binders and modulators, generating quantitative data on protein function.
What you'll do
- Build pooled screening workflows for protein-binding and functional readouts, from assay setup through data interpretation.
- Establish assay conditions, quantitative measures, and handoff plans with project teams.
- Analyze and present findings, inform experimental choices, and identify opportunities to advance drug programs and support IP filings.
What they ask for
- Hands-on experience designing and running pooled binding screens.
- Experience designing and building pooled DNA libraries and using next-generation sequencing to track enrichment.
- Ability to interpret complex screening data and write scripts in Python or a similar language.
- Quantitative reasoning, experimental judgment, and ownership of applied biology projects.
Nice to have
- Cell-culture and cell-line engineering experience for screening, such as CRISPR, lentiviral transduction, or transposon-based integration; membrane protein experience is highly preferred for one role.
- Familiarity with recombinant protein production, purification, or binding assays; computational modeling or statistical analysis experience is helpful.
Pay
$102,000 — $130,000 USD base salary per year
Tools
Python, CRISPR, lentiviral transduction, transposon-based integration, next-generation sequencing, Cursor
AI focus
Applies machine learning and AI-assisted coding tools to support pooled screening, experimental design, and data analysis.
Model-written summary · the original posting is authoritative