GSK
Oligo Discovery Process Chemistry Principal Scientist
$121K–$202K
USA - Massachusetts - Cambridge · On-site · Principal · Full-time · Posted Oct 8, 2026
- Experience
- 2–4+ years required; preferred qualification states 4+ years.
- Education
- PhD in chemistry, chemical biology, or a related field.
About the job
Leads discovery process chemistry for oligonucleotide therapeutics, developing and scaling synthesis and purification workflows and producing in vivo study material.
What you'll do
- Develop and troubleshoot milligram-to-gram SPOS routes for ASOs, siRNA, SSO, and RNA editors.
- Generate rodent- and NHP-scale in vivo material and develop chromatography and purification strategies that translate to larger-scale synthesis.
- Establish synthesis and purification methods and SOPs, and collaborate with analytical and conjugate chemistry teams.
What they ask for
- PhD in chemistry, chemical biology, or a related field.
- 2–4+ years of industry experience in oligonucleotide process chemistry, process discovery, or related synthesis/process roles.
- Hands-on milligram-to-gram solid-phase oligonucleotide synthesis experience, including method development, chromatography, and purification.
- Familiarity with mid-scale synthesizers and purification systems, Unicorn software, and LC/HRMS, UPLC, and LC/MS analytics.
Nice to have
- 4+ years of experience in oligonucleotide process chemistry, process discovery, oligo chemistry, or related fields.
- Experience generating rodent- and/or NHP-scale study material, translating discovery routes to larger scale, mentorship, project management, or oligonucleotide conjugation.
Pay
USD 121,275 to USD 202,125 annual base salary
Tools
SPOS, ÄKTA Oligosynt, Mermade12, ÄKTA Avant, Pure, Unicorn, LC/HRMS, UPLC
Model-written summary · the original posting is authoritative