Iambic Therapeutics
Principal Scientist, Medicinal Chemistry
$152K–$190K
San Diego HQ · Principal · Full-time · Posted Oct 5, 2026
- Experience
- BS with 15+ years, MS with 12+ years, or PhD with 8+ years’ experience.
- Education
- BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry.
About the job
Leads medicinal chemistry strategies and experiments to discover and optimize small-molecule drug candidates in collaboration with multidisciplinary and AI/ML teams.
What you'll do
- Identify lead molecules and optimize potency, selectivity, ADME, and PK properties through SAR analysis and hypothesis-driven design.
- Conduct synthetic chemistry and use parallel experimentation, automated synthesis, and high-throughput experimentation capabilities.
- Collaborate across R&D disciplines and with AI/ML teams to develop and apply predictive models for molecule design.
What they ask for
- BS, MS, or PhD in chemistry focused on synthetic organic chemistry.
- Small-molecule drug-discovery experience in biotechnology or pharmaceuticals, with a BS and 15+ years, MS and 12+ years, or PhD and 8+ years of experience.
- Experience advancing programs from leads to advanced candidates and optimizing compounds for potency, selectivity, ADME, and PK.
- Required experience working with computational chemists on project teams in drug-target design.
Pay
$152K – $190K (base salary)
Tools
AI/ML, automated synthesis, high-throughput experimentation, computational methods
AI focus
Collaborate with AI/ML teams to develop and implement predictive models that aid in designing new molecules; interface with teams working on AI-driven molecular generation and property predictions.
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