Isomorphic Labs
Research Leader (DMPK), Cambridge, MA
Cambridge, MA +1 · Full-time · Posted Sep 3, 2026
- Location
- Cambridge, MA
Cambridge, Massachusetts, United States - Experience
- 7–10+ years’ professional experience in a DMPK role.
- Education
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject.
About the job
Leads DMPK strategy for drug discovery projects, combining quantitative pharmacology and AI-first approaches to advance high-quality clinical candidates and improve drug-design models.
What you'll do
- Develop project-specific DMPK strategies, screening cascades, and mechanistic experiments.
- Integrate DMPK, pharmacodynamic, and toxicology data to support decisions, including dose and safety-window predictions.
- Collaborate with platform, chemistry, and pharmacology teams; optimize datasets and molecule design, and author regulatory DMPK sections.
What they ask for
- PhD in Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject.
- 7–10+ years’ professional DMPK experience in biotech or pharma, solving small-molecule drug-discovery problems and collaborating to deliver high-quality candidates.
- Experience developing DMPK and quantitative pharmacology packages for early clinical development, including authoring and reviewing regulatory documents.
- Experience partnering with Preclinical and Clinical teams; in-depth knowledge of biotransformation, PK modelling, and scaling ADME properties.
Nice to have
- Experience with peptides and other new modalities; advanced knowledge of PK/PD modelling.
- Good understanding of machine learning techniques; familiarity with Python and R.
Tools
Python, R
AI focus
Applies an AI-first approach to DMPK strategy and uses and helps optimize computational and AI ADME models; supports improvements to the drug-design platform.
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