Research Leader / Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

What you'll do

• Plan and oversee target-specific in vitro and in vivo pharmacology, PK/PD, and safety assessments, including CRO studies.
• Develop translational strategies, models, and biomarker plans to support patient selection, clinical proof of concept, and trial design.
• Interpret experimental data and provide strategic recommendations for project decisions, clinical translation, and IND filings.

What they ask for

• Ph.D. in Pharmacology, Immunology, Cancer Biology, Molecular Biology, or a related scientific discipline.
• 8+ years / 5+ years of professional experience in a Translational Sciences role within biotech, pharma, or a CRO setting.
• Experience leading biology or projects in small-molecule drug discovery programs, ideally through clinical candidate delivery.
• Expertise in translational models, TPPs and screening cascades, biomarker strategies, PK/PD, and managing CRO networks.

Nice to have

• Experience with strategic de-risking and SAR strategies; good understanding of medicinal chemistry concepts.
• General knowledge of machine learning modeling applied to biological systems and drug discovery.

Tools

in vivo, in vitro, PK/PD, CROs, ADMET, SAR, machine learning

AI focus

Provides biological expertise and experimental validation for ML-designed medicines, translates in silico predictions into physical validation protocols, and supplies data to improve predictive drug-design models.