Isomorphic Labs
Research Leader / Senior Scientist (Medicinal Drug Design), Cambridge, MA
Cambridge, MA +1 · Senior · Full-time · Posted Aug 11, 2026
- Location
- Cambridge, MA
Cambridge, Massachusetts, United States - Experience
- 8+ / 5+ years; the posting does not specify which level corresponds to each threshold.
- Education
- PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.
About the job
Lead medicinal chemistry drug discovery projects from initiation toward clinical candidate selection, while shaping AI tools and guiding their application to drug design.
What you'll do
- Lead drug discovery programs as a Project Lead or Medicinal Chemistry Lead, using modern discovery principles and synthetic organic chemistry.
- Provide technical direction to machine learning teams and collaborate across functions to improve and apply the AI platform.
- Manage CRO resources, develop intellectual property, prepare scientific proposals and reports, and represent the company to collaborators.
What they ask for
- PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.
- 8+ / 5+ years of professional experience in a Medicinal Chemistry role in biotech, pharma, or a CRO setting.
- Project leadership in drug discovery, experience driving a problem through structure-based drug design, and experience managing CRO resources.
- For people-management positions, experience leading and mentoring a high-performing scientific team.
Nice to have
- Experience applying fragment-based drug design approaches.
Tools
machine learning, AI, synthetic organic chemistry, structure-based drug design, fragment-based drug design
AI focus
Provide medicinal chemistry expertise and technical direction to improve the AI platform, then apply those improvements to drug discovery and design projects.
Model-written summary · the original posting is authoritative