Legend Biotech
Scientist II, CMC Pipeline Innovation
$111K–$145K
Somerset, New Jersey, United States · Full-time · Posted Aug 31, 2026
- Experience
- 0–3 years of relevant experience preferred for Ph.D. candidates; M.S. or B.S. candidates may be considered with a commensurate combination of additional industry, research, or technical experience.
- Education
- Ph.D. in Biology, Biomedical Engineering, Virology, Immunology, or a related field; M.S. or B.S. candidates with commensurate additional experience will also be considered.
- Visa sponsorship
- Applicants must be authorized to work in the United States. The company participates in E-Verify.
About the job
Develops and evaluates manufacturing, analytical, and characterization technologies—especially lentiviral vector purification—to improve cell and gene therapy processes and support technology transfer.
What you'll do
- Design, optimize, and scale up lentiviral vector downstream purification processes using chromatography and alternative separation technologies.
- Run feasibility, proof-of-concept, and characterization studies; analyze results and recommend whether technologies should be advanced, implemented, or discontinued.
- Support integration and transfer of successful technologies into development and manufacturing workflows, and communicate findings through reports and presentations.
What they ask for
- Ph.D. in Biology, Biomedical Engineering, Virology, Immunology, or a related field; candidates with an M.S. or B.S. and commensurate additional experience may also be considered.
- Hands-on experience with stirred-tank bioreactors, TFF, sterile filtration, and chromatography for biologics or advanced therapy products.
- Strong understanding of viral vector manufacturing, gene delivery, analytical methodologies, and molecular biology techniques.
- Experience with biostatistical tools and experimental design, including JMP (DoE) and GraphPad Prism.
Nice to have
- Familiarity with AI, machine learning, or other data-driven approaches applied to bioprocess development, characterization, or manufacturing.
- LVV process experience; exposure to HPLC, UHPLC, LC-MS/MS, or Raman spectroscopy; Mandarin.
Pay
$110,706 — $145,303 USD base pay
Tools
lentiviral vector (LVV), TFF, chromatography, HPLC, UHPLC, LC-MS/MS, JMP (DoE), GraphPad Prism
AI focus
AI, machine learning, and other data-driven approaches are a plus when applied to bioprocess development, analytical characterization, manufacturing innovation, and gene therapy manufacturing platforms.
Model-written summary · the original posting is authoritative