Legend Biotech
Senior Engineer / Principal Engineer, Vector Downstream
$146K–$192K
Somerset, New Jersey, United States · Principal · Full-time · Posted Sep 11, 2026
- Experience
- 6+ years with a PhD or 8+ years with an MS; additional experience and demonstrated technical leadership may be considered for Principal Engineer level.
- Education
- PhD preferred, or MS, in Chemical Engineering, Biomedical Engineering, Bioprocess Engineering, or a related field.
- Visa sponsorship
- Applicants must be authorized to work in the United States; employment eligibility is verified through E-Verify.
About the job
Designs, optimizes, models, and scales lentiviral-vector purification processes for cell therapy programs, supporting GMP manufacturing and process technology transfer.
What you'll do
- Develop and optimize downstream processes and mechanistic or hybrid models, using analytics and AI-enabled strategies to improve vector recovery, purity, and potency.
- Translate bench-scale processes to GMP manufacturing; support technology transfer and troubleshoot clinical production runs.
- Develop advanced process controls and author or review technical documents, including development reports, SOPs, and CMC regulatory sections.
What they ask for
- Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Bioprocess Engineering, or a related field.
- 6+ years (PhD) or 8+ years (MS) of process development or manufacturing experience in biotech or pharmaceuticals.
- Strong engineering knowledge of bioprocess modeling/simulation and strong technical experience in purification, chromatography, and TFF.
- Understanding of GMP manufacturing requirements and CMC strategies for clinical-stage product development.
Nice to have
- Experience with Python and/or MATLAB; lentiviral-vector experience or related viral vector, biologics, gene therapy, or advanced therapy process development.
- Experience developing vector processes for in vivo CAR-T generation and systemic delivery, or large-scale (>50L) purification processes; Mandarin is a plus.
Pay
$146,410 — $192,164 USD (base pay)
Tools
Python, MATLAB, AEX, SEC, HIC, TFF, MPC, State Estimators
AI focus
Builds model-first and AI-enabled development strategies and uses ML algorithms for modeling and clustering to generate process insights.
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