Legend Biotech
Sr. Scientist, Lentivirus Upstream Processing
$127K–$167K
Somerset, New Jersey, United States · Senior · Full-time · Posted Sep 1, 2026
- Experience
- 5-8 years (PhD) or 8+ years (MS) in process development or manufacturing within a biotech or pharmaceutical setting.
- Education
- Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
- Visa sponsorship
- Applicants must be authorized to work in the United States; employment eligibility is verified through E-Verify.
About the job
Designs, executes, and optimizes lentiviral vector upstream processes, from cell culture and transfection through bioreactor scale-up and GMP manufacturing support.
What you'll do
- Develop and optimize seed train, mammalian cell culture, transient transfection, and bioreactor processes for lentiviral vector production.
- Support process scale-up, technology transfer, and troubleshooting for clinical manufacturing; collaborate across technical teams.
- Document and communicate findings, and author or review development reports, SOPs, and regulatory submission materials.
What they ask for
- Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field.
- Hands-on mammalian cell culture, seed train expansion, feeding strategy, and viral-vector transient transfection optimization experience.
- Proficiency developing and implementing bioreactor scale-up and scale-down models.
- Understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials; direct experience with cell and lentiviral vector technologies.
Nice to have
- Lentivirus experience.
- Experience with large-scale (>50L, e.g., 200L/500L) upstream bioreactor processes; Mandarin is a plus.
Pay
$127,313 — $167,099 USD (base salary)
Tools
HEK293, HEK293T, stir-tank bioreactors, rocker bioreactors, GMP
Model-written summary · the original posting is authoritative