Legend Biotech
VP, Head of Preclinical Development
$294K–$387K
Somerset, New Jersey, United States · Director · Full-time · Posted Jul 21, 2026
- Experience
- Minimum 15 years of progressive preclinical drug development experience, including at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
- Education
- PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
- Visa sponsorship
- Applicants must be authorized to work in the United States; employment eligibility is verified through E-Verify.
About the job
Leads global preclinical development across the company’s pipeline, from candidate nomination through IND-enabling studies, and builds the team responsible for pharmacology and toxicology.
What you'll do
- Set preclinical strategy and scientific standards; integrate PK, PD, safety, and biodistribution data to inform clinical development and regulatory submissions.
- Lead preclinical development for cell and gene therapy modalities and own the nonclinical component of IND applications.
- Build and develop the preclinical team, oversee CRO relationships, and provide preclinical risk assessments for portfolio decisions.
What they ask for
- PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
- At least 15 years of progressive preclinical drug development experience, including at least 5 years in senior leadership with direct accountability for IND-enabling programs.
- Expertise in at least two of in vitro pharmacology, in vivo pharmacology, and toxicology, with working knowledge of the third; experience designing and overseeing GLP toxicology studies.
- Experience in cell therapy, gene therapy, or advanced therapy development; successful IND submissions with accountability for nonclinical pharmacology and toxicology sections.
Pay
$294,483 — $386,511 USD (base salary)
Tools
CAR-T, lentiviral vector-based in vivo CAR-T, GLP, PK, PD, CRO, IND
Model-written summary · the original posting is authoritative