Manifold Bio
Director, Oligo Team Lead
$195K–$239K
Boston +1 · Director · Full-time · Posted Aug 4, 2025
- Location
- Boston
Boston, Massachusetts, United States - Experience
- Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs.
- Education
- PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline).
About the job
Leads strategy and execution for tissue-targeted shuttled oligonucleotide therapeutic discovery programs, guiding scientific teams and advancing candidates toward clinical testing.
What you'll do
- Build and lead an oligonucleotide discovery team and lead 1–2 cross-functional drug discovery teams.
- Prioritize therapeutic targets, define target product profiles, and track program workplans.
- Develop screening and production systems using multiplexed in vivo screening capabilities; communicate progress and provide oligonucleotide expertise to partners.
What they ask for
- PhD in a relevant field.
- Minimum of 10 years post-PhD experience, including industry drug-discovery programs.
- Experience with multiple oligonucleotide modalities and backbone chemistries/modifications, and knowledge of oligo delivery technologies.
- Experience progressing oligonucleotide therapies from early discovery through IND-enabling preclinical activities or early clinical development; demonstrated scientific team leadership and mentoring.
Nice to have
- Experience designing and interpreting in vitro and in vivo oligonucleotide efficacy and safety systems.
- Experience optimizing oligonucleotide conjugates or platforms for oligo design, synthesis, and screening; understanding of oligo DMPK, toxicology, developability, and CMC.
Pay
$195,000-239,000 USD base salary
Tools
ASOs, siRNAs, aptamers, mRNA, LNPs
Model-written summary · the original posting is authoritative