Manifold Bio
Scientist, cDNA Display
$118K–$138K
Boston +1 · Full-time · Posted Mar 4, 2026
- Location
- Boston
Boston, Massachusetts, United States - Education
- PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or a related field.
About the job
Build and own an automated, high-throughput cell-free display platform for screening designed protein binders and generating data for AI-guided discovery models.
What you'll do
- Design, develop, and validate a cell-free display platform for diverse binder formats.
- Scale and automate high-throughput screening against therapeutic targets, collaborating with automation, ML, computational, and protein engineering teams.
- Support discovery and affinity maturation campaigns, and ensure screening data feeds model-training pipelines.
What they ask for
- PhD or equivalent experience in protein biochemistry, molecular biology, biological engineering, or a related field.
- Hands-on experience with cell-free selection systems such as cDNA display, mRNA display, or ribosome display.
- Strong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows.
- Experience with or strong interest in laboratory automation.
Nice to have
- Track record of automating complex laboratory workflows; background in therapeutic antibody discovery or protein engineering.
- Experience with computational protein design, ML data pipelines, or complex/non-traditional binder formats.
Pay
$118,000-138,000 USD base salary
Tools
cDNA display, mRNA display, ribosome display
AI focus
Generate high-quality binding data for training and improving computational protein design models within an AI-driven molecule discovery engine.
Model-written summary · the original posting is authoritative