NewLimit
Principal/Senior Scientist, Translational Biomarkers
$155K–$200K
South San Francisco +1 · Principal · Full-time · Posted Apr 17, 2026
- Location
- South San Francisco
South San Francisco, California, United States - Experience
- 5+ years of equivalent industry experience is stated as an alternative to the PhD; 3+ years of hands-on experience with quantitative bioanalytical assay platforms.
- Education
- PhD in molecular biology, biochemistry, cell biology, or a related field, or equivalent industry experience.
About the job
Leads discovery, development, and qualification of pharmacodynamic biomarker assays for NewLimit’s mRNA-LNP medicines in preclinical and IND-enabling studies.
What you'll do
- Discover PD biomarkers and develop and qualify assays across platforms for preclinical studies.
- Shape PD biomarker strategy, set advancement criteria, and contribute to regulatory submissions.
- Analyze and report bioanalytical data; support sample workflows, mentor research associates, and establish SOPs.
What they ask for
- PhD in molecular biology, biochemistry, cell biology, or a related field, or equivalent industry experience (5+ years).
- 3+ years of hands-on experience with quantitative bioanalytical assay platforms in complex biological matrices.
- Knowledge of bioanalytical method qualification and validation principles, including ICH M10 and fit-for-purpose frameworks.
- Experience delivering bioanalytical projects and with primary cell culture and tissue-derived sample workflows.
Nice to have
- Experience with bioanalytical method transfer and CRO management.
- Familiarity with preclinical drug development timelines, regulatory submissions, LNP-RNA biodistribution, or emerging therapeutic modalities.
Pay
$155,000 to $200,000 (USD, base salary)
Tools
RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS
Model-written summary · the original posting is authoritative