NewLimit
Scientist- Delivery Sciences-targeted LNPs (tLNPs)
$130K–$171K
South San Francisco +1 · Full-time · Posted Oct 14, 2026
- Location
- South San Francisco
South San Francisco, California, United States - Experience
- PhD route: 1–2 years of relevant work; MS route: 5 years of focused tLNP design experience.
- Education
- PhD in Pharmaceutical Sciences, Pharmaceutical Chemistry and Biochemistry, or a related discipline; or an MS.
About the job
Designs, formulates, and characterizes targeted lipid nanoparticles to deliver nucleic acid payloads to cells and tissues beyond the liver.
What you'll do
- Design LNP compositions and conjugation chemistries for targeting molecules, and plan their purification.
- Test targeting lipids using SAR-based approaches; use experimental data to guide tLNP design and optimization.
- Present findings and author protocols and technical reports; develop processes to support in vivo testing.
What they ask for
- PhD in a relevant discipline plus 1–2 years of relevant work, or an MS with 5 years of focused tLNP design experience.
- Hands-on experience designing, formulating, purifying, and characterizing targeted LNPs and conjugated lipids.
- Working knowledge of conjugation chemistry, linker design, and biorthogonal or site-specific handles.
- Practical purification and analytical characterization skills, including chromatography and methods such as LC-CAD, LC-UV, DLS, CE, bio-layer interferometry, and surface plasmon resonance.
Nice to have
- Familiarity with novel conjugation chemistries and reaction methods; targeting moiety optimization for immune or endothelial cells.
- Exposure to scale-up, CMC, or CDMO tech transfer; data visualization and statistical analysis using R, Python, or JMP.
Pay
$130,000 to $171,000 USD base salary
Tools
LNPs, LC-CAD, LC-UV, DLS, CE, R, Python, JMP
AI focus
Use AI-based SAR prediction tools for tLNP applications.
Model-written summary · the original posting is authoritative