NewLimit
Scientist, Metabolism
$130K–$165K
South San Francisco +1 · Full-time · Posted Sep 25, 2026
- Location
- South San Francisco
South San Francisco, California, United States - Experience
- 5+ years of equivalent industry experience is stated as an alternative to a Ph.D.; no separate years requirement is given.
- Education
- Ph.D. in cell biology, molecular biology, biochemistry, or a related field, or equivalent industry experience.
About the job
Develop and evaluate epigenetic reprogramming interventions and assays to restore hepatocyte function in age-related and metabolic liver disease.
What you'll do
- Develop assays and use preclinical liver disease models to measure hepatocyte function and evaluate therapeutic candidates.
- Deliver reprogramming perturbations to hepatocytes in vivo using transgenic manipulation methods, and analyze results to guide preclinical decisions.
- Collaborate across teams to design, build, and test interventions for aged and diseased hepatocytes.
What they ask for
- Ph.D. in cell biology, molecular biology, biochemistry, or a related field, or equivalent industry experience (5+ years).
- Experience with primary liver cell isolation and functional characterization.
- Experience working with mouse models of liver dysfunction.
- Experience with transgenic manipulation of liver cells ex vivo or in vivo, such as viral vectors or nucleic acid delivery.
Nice to have
- Contributed to a preclinical or clinical drug development program; or led preclinical mouse studies.
- Experience with single cell genomics or pooled screening approaches.
Pay
$130,000 to $165,000 (base salary)
Tools
viral vectors, lipid nanoparticles, CRISPR fitness screens, Perturb/CROP-seq
Model-written summary · the original posting is authoritative