NewLimit
Scientist, mRNA Downstream Purification
$120K–$155K
South San Francisco +1 · Full-time · Posted Oct 20, 2026
- Location
- South San Francisco
South San Francisco, California, United States - Experience
- Ph.D.: 0–3 years; M.S.: 5+ years; B.S.: 7+ years of relevant industry experience.
- Education
- Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field; or an M.S. or B.S.
About the job
Leads development, optimization, scale-up, and transfer of purification processes for mRNA drug substance.
What you'll do
- Develop and analyze mRNA purification processes, including automated workflows and scale-up from bench to pilot scale.
- Serve as downstream lead for CMC teams and support research-grade mRNA production runs.
- Transfer processes to CDMOs and support manufacturing, troubleshooting, and deviation investigations.
What they ask for
- Ph.D. in a related field with 0–3 years of relevant industry experience, or M.S. with 5+ years, or B.S. with 7+ years.
- Hands-on experience developing downstream purification processes for nucleic acids or other biologics.
- Hands-on experience with tangential flow filtration (TFF).
- Experience operating ÄKTA chromatography systems.
Nice to have
- Experience with nucleic acid or plasmid DNA purification, DoE, automated workflows, or CDMO process transfer.
- Familiarity with cGMP, phase-appropriate process development, or mRNA analytics such as HPLC, CGE, and dsRNA ELISA.
Pay
USD $120,000-155,000 base salary
Tools
mRNA, tangential flow filtration (TFF), ÄKTA, HPLC, CGE, dsRNA ELISA, Design of Experiments (DoE)
Model-written summary · the original posting is authoritative