NewLimit
Scientist/Senior Scientist
$130K–$180K
South San Francisco, CA +1 · Senior · Full-time · Posted Sep 17, 2025
- Location
- South San Francisco, CA
South San Francisco, California, United States - Experience
- 5+ years of equivalent industry experience; alternatively, a Ph.D. is requested.
- Education
- Ph.D. in cell biology, molecular biology, biochemistry or a related field, or equivalent industry experience.
About the job
Develops assays and pre-clinical models to measure age-related endothelial cell decline and evaluates reprogramming medicines for vascular applications.
What you'll do
- Develop functional assays and pre-clinical models for endothelial cell function; analyze results to inform pre-clinical decisions.
- Collaborate with Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale.
- Measure the effects of mRNA reprogramming medicines and engineer in vivo nucleic acid delivery methods for endothelial cells.
What they ask for
- Ph.D. in cell biology, molecular biology, biochemistry or a related field, or equivalent industry experience (5+ years).
- Experience with primary cell isolation and functional characterization.
- Experience working with mouse models, such as kidney, cardiovascular, or cognitive disease models.
- Experience with transgenic manipulation of primary cells ex vivo or in vivo, such as using viral vectors or nucleic acid delivery.
Nice to have
- History of contributing to a drug development program at the pre-clinical or clinical development stage.
- Experience leading pre-clinical mouse studies, single cell genomics, or pooled screening approaches.
Pay
$130,000 to $180,000 USD base salary
Tools
mRNA, viral vectors, nucleic acid delivery, single cell genomics, CRISPR fitness screens, Perturb/CROP-seq
AI focus
The role collaborates with Predictive Modeling and Functional Genomics teams to test reprogramming hypotheses at scale; the posting also describes the company’s use of machine learning models.
Model-written summary · the original posting is authoritative