Novartis
Principal Scientist I/II, Oligonucleotide Chemistry & Innovation
$108K–$202K
Cambridge (USA) · Principal · Full-time · Posted Aug 28, 2026
- Experience
- At least five years synthesizing therapeutic oligonucleotides in an industry or research setting.
- Education
- Doctor of Philosophy in Chemistry or a related scientific discipline.
About the job
Leads development of novel oligonucleotide chemistries and advances RNA therapeutic candidates from discovery through preclinical stages.
What you'll do
- Synthesize, purify, characterize, and analyze chemically modified oligonucleotides and conjugates; develop and optimize chemistries and synthetic routes.
- Collaborate across therapeutic programs, mentor scientists, improve laboratory workflows, and establish standard operating procedures.
- Operate, troubleshoot, and maintain synthesis and analytical instruments.
What they ask for
- PhD in Chemistry or a related scientific discipline.
- At least five years of experience synthesizing therapeutic oligonucleotides in an industry or research setting.
- Expertise in solid-phase oligonucleotide synthesis, deprotection, purification, characterization, phosphoramidite chemistry, and developing novel chemistries and conjugates.
- Hands-on experience with automated oligonucleotide synthesizers and analytical instrumentation, plus understanding of RNA therapeutics, including small interfering ribonucleic acid and antisense oligonucleotides.
Pay
108,500.00 - 201,500.00 USD Annual (base salary)
Tools
high performance liquid chromatography, liquid chromatography mass spectrometry, automated oligonucleotide synthesizers, phosphoramidite chemistry
Model-written summary · the original posting is authoritative