Output Biosciences
Head of Biology
New York, NY +1 · On-site · Director · Full-time · Posted Oct 23, 2026
- Location
- New York, NY
San Francisco, CA - Experience
- 3+ years of post-doctoral or industry research experience.
- Education
- PhD in computational biology, biophysics, structural biology, molecular biology, or a related biological field.
About the job
Leads the experimental biology feedback loop for Output’s models, translating biological problems into experiments, data and modeling priorities, and workflows.
What you'll do
- Design experiments and manage CRO partners for synthesis, assays and testing; interpret results and feed findings back into model development.
- Translate biological requirements and experimental findings into priorities for data construction, modeling and evaluation.
- Collaborate with engineering, model and data teams to build biology-specific tools and workflows that automate experimental decision-making.
What they ask for
- PhD in computational biology, biophysics, structural biology, molecular biology, or a related biological field.
- Deep understanding of protein biology, protein-ligand interactions, and sequence/structure relationships to biological function.
- Experience designing biological experiments and working with CROs for synthesis and experimental validation.
- Experience with protein language models or machine learning applied to biological sequences and structures; strong Python programming skills.
Nice to have
- Structural biology expertise; active learning or iterative experimental design experience.
- Hands-on wet lab experience; experience across therapeutic modalities including peptides; or experience automating biological analysis workflows.
Tools
Python
AI focus
Applies biological expertise to improve biological reasoning models through experimental validation, active learning, and biology-specific agent skills and workflows.
Model-written summary · the original posting is authoritative